环氧化酶-2启动子765C增加中国人群消化道癌症风险：一项荟萃分析。

Cyclooxygenase-2 promoter 765C increase of digestive tract cancer risk in the Chinese population: a meta-analysis.

作者信息

Xu Yan-Song, Zhao Bo, Long Chen-Yan, Li Hui, Lu Xing, Liu Gang, Tang Xiao-Zhun, Tang Wei-Zhong

机构信息

Department of Emergency, First Affiliated Hospital, Guangxi Medical University, Nanning, China E-mail :

出版信息

Asian Pac J Cancer Prev. 2014;15(11):4563-6. doi: 10.7314/apjcp.2014.15.11.4563.

DOI:10.7314/apjcp.2014.15.11.4563

PMID:24969885

Abstract

BACKGROUND

To evaluate relationship between the cyclooxygenase-2 promoter 765G/C polymorphism and digestive cancer risk in China.

MATERIALS AND METHODS

A literature search through February 2014 was performed using PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure (CNKI) databases, and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs.

RESULTS

In total, 9 articles with 3,263 cases and 4,858 controls were included in this meta-analysis.The pooled OR (95%CIs) in the co-dominant model (GC vs GG) was 1.56 [1.19, 2.06], and in the dominant model ((CC+GC) vs GG), the pooled OR was 1.59 [1.21, 2.09] in overall cancers. In the subgroup analysis, stratified by cancer type, significant associations were found that the-765C allele had increased pancreatic cancer and gastric risk. No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found.

CONCLUSIONS

These findings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreatic cancer risk.

摘要

背景

评估中国人群中环氧合酶-2（COX-2）启动子765G/C多态性与消化系统癌症风险之间的关系。

材料与方法

通过检索PubMed、中国生物医学文献数据库（CBM）和中国知网（CNKI）数据库，纳入截至2014年2月的相关文献，并使用RevMan 5.2软件进行荟萃分析，计算比值比（OR）及95%可信区间（CI）。

结果

本荟萃分析共纳入9篇文献，包含3263例病例和4858例对照。在共显性模型（GC vs GG）中，总体癌症的合并OR（95%CI）为1.56 [1.19, 2.06]；在显性模型（(CC + GC) vs GG）中，合并OR为1.59 [1.21, 2.09]。亚组分析按癌症类型分层后发现，-765C等位基因与胰腺癌和胃癌风险增加显著相关。未发现COX-2 -765G/C多态性与肝癌和结直肠癌风险存在显著关联。