Chen Xi, Dong Weiguo, Wang Jun, Lyu Xiaoguang, Lei Hongbo, Liu Ya
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. Email:
Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Jan;48(1):62-6.
To explore the correlation between polymorphism of cyclooxygenase-2 (COX-2) -765G>C and susceptibility to colorectal cancer.
All eligible case-control studies published up to March 2013 were searched out from PubMed, EMABSE, CJFD, CBM, CNKI, VIP and WanFang databases, while 99 articles were concluded. Two reviewers independently identified the literature according to inclusion and exclusion criteria. Meta-analysis was performed using RevMan 5.1 and Stata 12.0 software.
A total of eleven studies comprising 3432 cases and 5286 controls were finally included. The included studies showed good homogeneity in the three genetic models, except the model of GC/GG genotype (I(2) = 52%, P = 0.03). Overall, there were no significant association between polymorphism of COX-2-765G>C and the susceptibility to colorectal cancer (dominant model: (GC+CC)/GG: OR = 1.08, 95%CI:0.96-1.21; recessive model:CC/(GC+GG): OR = 1.09, 95%CI:0.76-1.56; GC/GG: OR = 1.05, 95%CI:0.87-1.28; CC/GG: OR = 1.11, 95%CI:0.77-1.60). In stratification analysis by ethnicity, we observed that the polymorphism of COX-2 -765G>C could increase the susceptibility to colorectal cancer among yellow populations ((GC+CC)/GG: OR = 1.41, 95%CI:1.15-1.75; GC/ GG: OR = 1.48, 95%CI:1.15-1.90), but there was no significant association found among Caucasian populations.
This meta-analysis suggested that the polymorphism of COX-2 -765G>C may increase the susceptibility to colorectal cancer in the yellow population.
探讨环氧化酶-2（COX-2）-765G>C多态性与结直肠癌易感性之间的相关性。
从PubMed、EMABSE、CJFD、CBM、CNKI、VIP和万方数据库中检索截至2013年3月发表的所有符合条件的病例对照研究，共纳入99篇文章。两名评价员根据纳入和排除标准独立筛选文献。采用RevMan 5.1和Stata 12.0软件进行Meta分析。
最终纳入11项研究，共3432例病例和5286例对照。纳入的研究在三种遗传模型中显示出良好的同质性，但GC/GG基因型模型除外（I(2)=52%，P=0.03）。总体而言，COX-2-765G>C多态性与结直肠癌易感性之间无显著关联（显性模型：(GC+CC)/GG：OR=1.08，95%CI：0.96-1.21；隐性模型：CC/(GC+GG)：OR=1.09，95%CI：0.76-1.56；GC/GG：OR=1.05，95%CI：0.87-1.28；CC/GG：OR=1.11，95%CI：0.77-1.60）。在按种族进行的分层分析中，我们观察到COX-2-765G>C多态性可增加黄种人群患结直肠癌的易感性（(GC+CC)/GG：OR=1.41，95%CI：1.15-1.75；GC/GG：OR=1.48，95%CI：1.15-1.90），但在白种人群中未发现显著关联。
该Meta分析表明，COX-2-765G>C多态性可能增加黄种人群患结直肠癌的易感性。
