Mandache Eugen, Stancu Simona, Ismail Gener, Penescu Mircea
Department of Nephropathology, "Carol Davila" Clinical Hospital for Nephrology, Bucharest, Romania;
Rom J Morphol Embryol. 2014;55(2):459-62.
Two variants of focal segmental glomerulosclerosis are known to present epithelial hypercellularity in the Bowman's space, namely the collapsing and the cellular types. This epithelial cell proliferation may get features of either pseudocrescent or tubular profiles. Our case of collapsing focal segmental glomerulosclerosis has been ultrastructurally investigated concerning the proliferating epithelial cell type: parietal versus visceral. Based on the cellular organelles, especially on the ubiquitous presence of desmosomes, the authors are endorsing, with ultrastructural arguments, the opinion favoring the parietal epithelial cells (PEC) as the proliferating cell type. It is also taken into consideration the eventual change of PECs phenotype in contact with the glomerular tuft components like the glomerular basement membrane.
已知局灶节段性肾小球硬化的两种变体在肾小囊腔内表现为上皮细胞增生，即塌陷型和细胞型。这种上皮细胞增殖可能具有假新月体或肾小管样特征。我们对塌陷型局灶节段性肾小球硬化病例进行了超微结构研究，以探讨增殖上皮细胞的类型：壁层上皮细胞与脏层上皮细胞。基于细胞器，特别是桥粒的普遍存在，作者从超微结构角度支持壁层上皮细胞（PEC）为增殖细胞类型的观点。同时也考虑了PEC与肾小球毛细血管袢成分（如肾小球基底膜）接触时表型的最终变化。
