Wishahi M, el-Baz H G, Shaker Z A
Department of Urology, Theodor Bilharz Research Institute, Cairo, Egypt.
Eur Urol. 1989;16(2):138-43. doi: 10.1159/000471552.
This study is a search for the genetic susceptibility of Egyptians to Schistosoma haematobium infestation with its various bladder complications, including cancer. 80 bilharzial patients, 20 with simple bilharzial bladder cystitis, 30 with bilharzial bladder lesions, and 30 with bilharzial bladder cancer, as well as 35 normal Egyptian controls were studied. All patients were typed for HLA-A, B, C and DR antigens using the microlymphocytotoxicity test. HLA-A9 and its split Aw24 antigens were found to be negatively associated with the disease. As for the antigens with positive associations, HLA-B7 was significantly increased in the simple bilharzial cystitis group. In the bilharzial bladder cancer group, HLA-B16 and Cw2 antigens had positive associations. These findings might support the genetic control of the disease or the presence of an immune response and/or immune suppression genes which are in linkage disequilibrium with these HLA antigens and they control the susceptibility and pathological sequences of the disease.
本研究旨在探寻埃及人对埃及血吸虫感染及其各种膀胱并发症（包括癌症）的遗传易感性。研究了80例血吸虫病患者，其中20例患有单纯血吸虫性膀胱膀胱炎，30例患有血吸虫性膀胱病变，30例患有血吸虫性膀胱癌，以及35名正常埃及对照者。使用微量淋巴细胞毒性试验对所有患者进行HLA - A、B、C和DR抗原分型。发现HLA - A9及其裂解抗原Aw24与该疾病呈负相关。至于呈正相关的抗原，HLA - B7在单纯血吸虫性膀胱炎组中显著增加。在血吸虫性膀胱癌组中，HLA - B16和Cw2抗原呈正相关。这些发现可能支持该疾病的遗传控制，或存在与这些HLA抗原处于连锁不平衡状态的免疫反应和/或免疫抑制基因，它们控制着该疾病的易感性和病理过程。
