蓝藻代谢产物念珠藻二酮A的全合成：发现其对刚地弓形虫的抗寄生虫活性。
Total synthesis of the cyanobacterial metabolite nostodione A: discovery of its antiparasitic activity against Toxoplasma gondii.
作者信息
McNulty J, Keskar K, Bordón C, Yolken R, Jones-Brando L
机构信息
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada L8S 4M1.
出版信息
Chem Commun (Camb). 2014 Aug 18;50(64):8904-7. doi: 10.1039/c4cc03904a.
PMID:24970332
Abstract
A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.
摘要
报道了蓝藻天然产物念珠藻二酮A的全合成，涉及一种汇聚式、多样化导向的路线。制备了一小批结构类似物，并首次报道了它们对原生动物寄生虫弓形虫的细胞毒性和抗侵袭活性。
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