Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii.
作者信息
McNulty James, Keskar Kunal, Jenkins Hilary A, Werstiuk Nick H, Bordón Claudia, Yolken Robert, Jones-Brando Lorraine
机构信息
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, CanadaL8S 4M1.
出版信息
Org Biomol Chem. 2015 Oct 21;13(39):10015-24. doi: 10.1039/c5ob01506e.
PMID:26291306
Abstract
A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.
摘要
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