McNulty James, Keskar Kunal, Jenkins Hilary A, Werstiuk Nick H, Bordón Claudia, Yolken Robert, Jones-Brando Lorraine
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, CanadaL8S 4M1.
Org Biomol Chem. 2015 Oct 21;13(39):10015-24. doi: 10.1039/c5ob01506e.
A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.
