由CD8 + T淋巴细胞产生的一种可扩散淋巴因子可抑制HIV复制。
A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.
作者信息
Walker C M, Levy J A
机构信息
Department of Medicine, University of California, School of Medicine, San Francisco 94143.
出版信息
Immunology. 1989 Apr;66(4):628-30.
Peripheral blood CD8+ T lymphocytes from human immunodeficiency virus (HIV)-infected individuals suppress replication of HIV in peripheral blood mononuclear cells (PBMC). This anti-viral activity appears to be mediated in part by a diffusible factor. Production of this lymphokine varies among infected individuals and may reflect the intrinsic ability of an individual's CD8+ cells to control HIV infection. In some cases in which factor activity is not apparent, contact of the CD8+ cells with infected CD4+ cells can produce for suppression of virus replication. These observations could lead to approaches for enhancing anti-viral responses in HIV-infected individuals.
来自人类免疫缺陷病毒（HIV）感染者的外周血CD8 + T淋巴细胞可抑制HIV在外周血单核细胞（PBMC）中的复制。这种抗病毒活性似乎部分由一种可扩散因子介导。这种淋巴因子的产生在受感染个体中各不相同，可能反映了个体CD8 +细胞控制HIV感染的内在能力。在某些因子活性不明显的情况下，CD8 +细胞与受感染的CD4 +细胞接触可产生病毒复制抑制作用。这些观察结果可能会带来增强HIV感染者抗病毒反应的方法。
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