感染克氏锥虫的CBA小鼠免疫反应的早期阶段。

The early phase of the immune response of CBA mice infected with Trypanosoma cruzi.

作者信息

Camargo I J, Sakurada J K, Zucato M R, de Araújo P M, de Araújo Rangel H

机构信息

Depto. Microbiologia e Imunologia, Instituto de Biologia, UNICAMP, São Paulo, Brasil.

出版信息

Immunol Lett. 1989 Feb;20(3):213-6. doi: 10.1016/0165-2478(89)90082-5.

DOI:10.1016/0165-2478(89)90082-5

PMID:2497066

Abstract

Mice injected with 10(5) culture trypomastigotes (CT) survived the 30-day observation period while those injected with the same number of bloodstream trypomastigotes (BT) died in 10 +/- 1 days. As early as 24 h after injection of CT the mice displayed an increased resistance to Trypanosoma cruzi as indicated by an increased longevity when challenged with lethal doses of BT. The phagocytic activity of mice injected 24-72 h earlier with CT is increased, while that of mice injected with BT is decreased. The data suggest that parasite factors acting on the early phase of the immune response play a role in the outcome of the infection.

摘要

注射10⁵个培养型锥鞭毛体（CT）的小鼠在30天观察期内存活，而注射相同数量血液内锥鞭毛体（BT）的小鼠在10±1天内死亡。早在注射CT后24小时，当用致死剂量的BT攻击时，小鼠的寿命延长，这表明其对克氏锥虫的抵抗力增强。提前24 - 72小时注射CT的小鼠吞噬活性增强，而注射BT的小鼠吞噬活性降低。数据表明，作用于免疫反应早期阶段的寄生虫因素在感染结果中起作用。