Kaneko Megumi, Stryker Michael P
Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States Department of Physiology, University of California, San Francisco, San Francisco, United States.
Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States Department of Physiology, University of California, San Francisco, San Francisco, United States
Elife. 2014 Jun 26;3:e02798. doi: 10.7554/eLife.02798.
Recovery from sensory deprivation is slow and incomplete in adult visual cortex. In this study, we show that visual stimulation during locomotion, which increases the gain of visual responses in primary visual cortex, dramatically enhances recovery in the mouse. Excitatory neurons regained normal levels of response, while narrow-spiking (inhibitory) neurons remained less active. Visual stimulation or locomotion alone did not enhance recovery. Responses to the particular visual stimuli viewed by the animal during locomotion recovered, while those to another normally effective stimulus did not, suggesting that locomotion promotes the recovery only of the neural circuits that are activated concurrent with the locomotion. These findings may provide an avenue for improving recovery from amblyopia in humans.DOI: http://dx.doi.org/10.7554/eLife.02798.001.
成年视觉皮层从感觉剥夺中恢复的过程缓慢且不完全。在本研究中，我们发现运动过程中的视觉刺激可增加初级视觉皮层中视觉反应的增益，显著促进小鼠的恢复。兴奋性神经元恢复了正常的反应水平，而窄峰放电（抑制性）神经元的活性仍然较低。单独的视觉刺激或运动并不能促进恢复。动物在运动过程中所观看的特定视觉刺激的反应得到了恢复，而对另一种通常有效的刺激的反应则未恢复，这表明运动仅促进了与运动同时被激活的神经回路的恢复。这些发现可能为改善人类弱视的恢复提供一条途径。DOI: http://dx.doi.org/10.7554/eLife.02798.001 。
