Mohseni Sakineh Moaid, Moez Nafiseh, Naghizadeh Mohammad Mehdi, Abbasi Maryam, Khodashenas Zohreh
Department of Gynecology and Obstetrics, Shahed University of Medical Science Tehran, Iran.
Shahed University of Medical Science, Tehran, Iran.
J Family Reprod Health. 2013 Jun;7(2):95-101.
To determine the value of random urinary protein to creatinine ratio (UPCR) for diagnosis of proteinuria in pregnant women with preeclampsia. Preeclampsia is the most common complication of pregnancy and one of the main causes of maternal mortality. So, early diagnosis of preeclampsia is very important.
In this cross-sectional study 66 pregnant women suspected preeclampsia at ≥24 week of gestational age and BP ≥ 140/90 mm/Hg were checked by two urine samples of 10am and 4pm to determine random UPCR, as well as a 24-hour urine sample to evaluate 24-hour protein excretion.
The result revealed that 74.2% of the studied population had significant proteinuria. There was a correlation between UPCR and 24-hour urine protein excretion. Pearson's correlation coefficient was 0.502 at 10am and 0.428 at 4pm. The best cutoff for the random urine protein to creatinine ratio at 10am was 0.470 with sensitivity and specificity equal to 87.5% and 84.2%, respectively. The best cutoff for the random UPCR at 4pm was 0.595 with sensitivity and specificity equal to 91.7% and 94.7%, respectively.
Result of 24-hour urine collection showing random UPCR is considered as an appropriate situated method for emergency time.
确定随机尿蛋白与肌酐比值（UPCR）在子痫前期孕妇蛋白尿诊断中的价值。子痫前期是妊娠最常见的并发症，也是孕产妇死亡的主要原因之一。因此，子痫前期的早期诊断非常重要。
在这项横断面研究中，对66例孕龄≥24周且血压≥140/90 mmHg疑似子痫前期的孕妇，采集上午10点和下午4点的两份尿液样本以测定随机UPCR，并采集24小时尿液样本以评估24小时尿蛋白排泄量。
结果显示，74.2%的研究人群存在显著蛋白尿。UPCR与24小时尿蛋白排泄量之间存在相关性。上午10点时Pearson相关系数为0.502，下午4点时为0.428。上午10点随机尿蛋白与肌酐比值的最佳截断值为0.470，敏感性和特异性分别为87.5%和84.2%。下午4点随机UPCR的最佳截断值为0.595，敏感性和特异性分别为91.7%和94.7%。
24小时尿样检测结果显示随机UPCR被认为是紧急情况下一种合适的方法。
