两种不同注射用避孕方法的比较：醋酸甲羟孕酮长效避孕针（DMPA）和复方醋酸甲羟孕酮注射液（Cyclofem）
Comparison of Two Different Injectable Contraceptive Methods: Depo-medroxy Progesterone Acetate (DMPA) and Cyclofem.
作者信息
Veisi Firoozeh, Zangeneh Maryam
机构信息
Department of Obstetrics & Gynecology, High Risk Pregnancy Research Center, Kermanshah University of Medical Science, Kermanshah, Iran.
出版信息
J Family Reprod Health. 2013 Sep;7(3):109-13.
OBJECTIVE
To compare side effects between users of two kinds of injectable contraceptives (Depo-medroxy progesterone acetate and Cyclofem).
MATERIALS AND METHODS
This cross-sectional descriptive study included 250 women, aged 18-40 years, using Depo-medroxy progesterone acetate (DMPA) or Cyclofem. The volunteers were examined six months after using contraceptive, and they were asked about following symptoms: weight changes, irregular bleeding, dysparounia, vaginal dryness, headache, breast pain, bone pain, and discontinuation reason. The data were analyzed by statistical methods.
RESULTS
THE IMPORTANT SIDE EFFECTS OF DMPA WERE: irregular bleeding (93.60%), weight gain (48%), bone pain (24%) and vaginal dryness (10.40%), while the side effects in the Cyclofem group were: irregular bleeding (65.60%), headache (14.4%) and breast sensitivity (20%). Bleeding pattern changes were the most important problem leading to discontinuation of both contraceptive methods in our participants.
CONCLUSION
The results of the study showed that the most important problem in both groups was change in bleeding pattern. Proper consulting by a trained expert reduces the high amount of discontinuation and their failure rates.
目的
比较两种注射用避孕药（醋酸甲羟孕酮长效避孕针和复方庚酸炔诺酮注射液）使用者的副作用。
材料与方法
这项横断面描述性研究纳入了250名年龄在18至40岁之间、使用醋酸甲羟孕酮长效避孕针（DMPA）或复方庚酸炔诺酮注射液的女性。志愿者在使用避孕药六个月后接受检查，并被询问以下症状：体重变化、不规则出血、性交困难、阴道干燥、头痛、乳房疼痛、骨痛以及停药原因。数据采用统计学方法进行分析。
结果
醋酸甲羟孕酮长效避孕针的主要副作用为：不规则出血（93.60%）、体重增加（48%）、骨痛（24%）和阴道干燥（10.40%），而复方庚酸炔诺酮注射液组的副作用为：不规则出血（65.60%）、头痛（14.4%）和乳房敏感（20%）。出血模式改变是导致我们研究参与者停用这两种避孕方法的最重要问题。
结论
研究结果表明，两组中最重要的问题都是出血模式改变。由训练有素的专家进行适当咨询可降低高停药率及其失败率。
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