Piya-Anant M, Koetsawang S, Patrasupapong N, Dinchuen P, d'Arcangues C, Piaggio G, Pinol A
Siriraj Family Health Research Centre, Department of Obstetrics and Gynecology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Contraception. 1998 Jan;57(1):23-8. doi: 10.1016/s0010-7824(97)00203-5.
A total of 100 women who were using depot medroxyprogesterone acetate (DMPA) for contraception and who had experienced at least 6 months of drug induced amenorrhea, were randomized to either switching their method of contraception to Cyclofem, or continuing with DMPA. At the end of 6 months, 82% of the Cyclofem users had experienced some vaginal bleeding, compared with 10% of DMPA users. Time to resumption of vaginal bleeding was related to the duration of DMPA use to the duration of DMPA induced amenorrhea, and to the body mass index of the user. Over the 6 months of follow-up, 94% of Cyclofem users complained of some side effects, compared with 22% of DMPA users. The most frequently cited problems among Cyclofem users included breast tenderness, abdominal pain, and dysmenorrhea; yet a third of these women opted to stay on Cyclofem at the end of the study. It is concluded that switching to Cyclofem is a new option for DMPA users who are concerned about amenorrhea. Although using Cyclofem in this setting will not meet the needs of all such women, its effectiveness in inducing vaginal bleeding justifies a trial in those who have no contraindication to estrogen treatment.
共有100名正在使用醋酸甲羟孕酮避孕针（DMPA）且经历了至少6个月药物性闭经的女性，被随机分为两组，一组将避孕方法换成Cyclofem，另一组继续使用DMPA。6个月结束时，82%的Cyclofem使用者出现了一些阴道出血，而DMPA使用者中这一比例为10%。恢复阴道出血的时间与使用DMPA的时长、DMPA导致闭经的时长以及使用者的体重指数有关。在6个月的随访期内，94%的Cyclofem使用者抱怨有一些副作用，而DMPA使用者中这一比例为22%。Cyclofem使用者中最常提到的问题包括乳房胀痛、腹痛和痛经；然而，三分之一的此类女性在研究结束时选择继续使用Cyclofem。结论是，对于担心闭经的DMPA使用者来说，换成Cyclofem是一种新的选择。虽然在这种情况下使用Cyclofem不能满足所有此类女性的需求，但其诱导阴道出血的有效性证明了在那些没有雌激素治疗禁忌证的女性中进行试验是合理的。
