Sakhavar Nahid, Kaveh Mania, Sadegi Kambiz
Obstetrics & Gynecologist Department, Zahedan University of Medical Science, Zahedan, Iran.
Anesthesiology Department, Zabol University of Medical Science, Zabol, Iran.
J Family Reprod Health. 2014 Mar;8(1):1-5.
To compare the effectiveness of letrozole and clomiphene citrate (CC) on uterine blood flow rate in patients with unexplained infertility.
In this randomized clinical trial 90 women with unexplained infertility referred to a university clinic from January 2011- December 2013 were enrolled. Thirty patients were randomized for letrozole, 30 patients for CC and 3o patients for control group. On the day 3 of cycle the patients were given letrozole 2.5mg/day or CC 100 mg /day orally or did not receive any treatment. Resistance index (RI) and pulsatility index (PI) of uterine artery were calculated and chemical pregnancy rate was evaluated.
Mean age was 26.4±3.2 (20-33) and mean BMI was 26.3± 3.2. After treatment using ultrasonography the Resistance index (RI) and Pulsatility index (PI) showed no significant difference among three groups (P > 0.05). Pregnancy rate in letrozole group (58%) was more in comparison to CC (53.6%) and control groups (46%) but the difference was not significant (P > 0.05).
Our study showed that letrozole and clomiphene citrate have comparable impact on uterine blood flow and pregnancy rate in women with unexplained infertility.
比较来曲唑与枸橼酸氯米芬（CC）对不明原因不孕症患者子宫血流速度的疗效。
在这项随机临床试验中，纳入了2011年1月至2013年12月转诊至一家大学诊所的90例不明原因不孕症女性。30例患者随机接受来曲唑治疗，30例患者接受CC治疗，30例患者作为对照组。在月经周期第3天，患者口服来曲唑2.5mg/天或CC 100mg/天，或不接受任何治疗。计算子宫动脉的阻力指数（RI）和搏动指数（PI），并评估化学妊娠率。
平均年龄为26.4±3.2（20 - 33岁），平均体重指数为26.3±3.2。治疗后超声检查显示，三组之间的阻力指数（RI）和搏动指数（PI）无显著差异（P>0.05）。来曲唑组的妊娠率（58%）高于CC组（53.6%）和对照组（46%），但差异不显著（P>0.05）。
我们的研究表明，来曲唑和枸橼酸氯米芬对不明原因不孕症女性的子宫血流和妊娠率有相当的影响。
