Schwalb H, Eckmann F, van Eimeren W
Fortschr Neurol Psychiatr Grenzgeb. 1978 Sep;46(9):484-90.
Within the scope of an epidemiologic study on risk factors and coronary heart diseases, 1726 mentally ill, aged 40-69, under permanent hospitalization were examined electrocardiographically. There were few pronounced indications of a relationship between pathological ECG findings and psychopharmaca. ECG changes were rarest among patients treated exclusively with non-tricyclic drugs, and most often among those patients who received tricyclics and non-tricyclics simultaneously. Statistically ascertained, however, was only the connection with lesser pathological changes in the rest and load ECG's (T-flattening). In this connection, these disturbances appeared more often among women. A reciprocal effect between sex and the influence of psychopharmaca appeared on the ECG. Contrary to males, females under treatment with tricyclica or with several psychopharmaca simultaneously showed more ECG changes than those treated without medication.
在一项关于危险因素与冠心病的流行病学研究范围内，对1726名年龄在40至69岁、长期住院的精神病患者进行了心电图检查。病理心电图结果与精神药物之间几乎没有明显的关联迹象。心电图变化在仅接受非三环类药物治疗的患者中最为罕见，而在同时接受三环类和非三环类药物治疗的患者中最为常见。然而，经统计学确定的只是静息和负荷心电图中较小病理变化（T波低平）的关联。在这方面，这些紊乱在女性中更为常见。性别与精神药物的影响之间在心电图上呈现出相互作用。与男性相反，接受三环类药物治疗或同时接受多种精神药物治疗的女性比未接受药物治疗的女性表现出更多的心电图变化。
