一种用于测定神经毒素β-N-草酰-L-α，β-二氨基丙酸的新型电位传感器。

A novel potentiometric sensor for determination of neurotoxin β-N-oxalyl-L-α, β-diaminopropionic acid.

作者信息

Isildak Omer, Saymaz Furkan, Karadag Ahmet, Korkmaz Nesrin Okumus, Attar Azade

机构信息

Department of Chemistry, Faculty of Science and Arts, Gaziosmanpasa University, 60240 Tokat, Turkey.

Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Esenler, 34210 Istanbul, Turkey.

出版信息

Biomed Res Int. 2014;2014:251653. doi: 10.1155/2014/251653. Epub 2014 May 20.

DOI:10.1155/2014/251653

PMID:24971325

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4054862/

Abstract

A novel potentiometric sensor based on ionophore (Cd(NH2CH2CH2OCH2CH2OCH2CH2NH2)Ag3(CN)5) for the determination of β-N-oxalyl-L-α, β-diaminopropionic acid (ODAP) is developed. The ODAP-selective membrane sensor demonstrates high sensitivity and short response time. The detection limit of the ODAP-selective membrane sensor is about 2 × 10(-6) mol L (-1) and the response time is shorter than 6 s. The linear dynamic range of the ODAP-selective membrane sensor is between ODAP concentrations of 1.0 × 10(-2) and 1 × 10(-6) mol L (-1). The ODAP-selective membrane sensor exhibits good operational stability for at least one week in dry conditions at 4-6°C. It has a reproducible and stable response during continuous work for at least 10 h with a relative standard deviation of 0.28% (n = 18).

摘要

开发了一种基于离子载体（Cd(NH2CH2CH2OCH2CH2OCH2CH2NH2)Ag3(CN)5）的新型电位传感器，用于测定β-N-草酰-L-α,β-二氨基丙酸（ODAP）。ODAP选择性膜传感器具有高灵敏度和短响应时间。ODAP选择性膜传感器的检测限约为2×10(-6) mol L (-1)，响应时间短于6 s。ODAP选择性膜传感器的线性动态范围为ODAP浓度在1.0×10(-2)至1×10(-6) mol L (-1)之间。ODAP选择性膜传感器在4-6°C干燥条件下至少一周内表现出良好的操作稳定性。在连续工作至少10小时期间，它具有可重现且稳定的响应，相对标准偏差为0.28%（n = 18）。