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新型三明治型聚氰基银(I)酸钾配合物:合成、表征及酶活性

New sandwich-type polymeric potassium-dicyanoargentate(I) complex: synthesis, characterization and enzymatic activity.

作者信息

Korkmaz Nesrin

机构信息

Department of Biotechnology, Faculty of Science, Bartın University, Bartın Turkey.

出版信息

Turk J Chem. 2020 Aug 18;44(4):1110-1121. doi: 10.3906/kim-2004-42. eCollection 2020.

Abstract

Coordination compounds containing dicyanoargentate(I) have remarkable biological potential due to their therapeutic antibacterial, antifungal, antibiofilm, and anticancer properties. In this study, a new dicyanoargentate(I)-based complex was synthesized and characterized by various procedures (elemental, thermal, FT-IR for complex) involving crystal analysis of the complex. In addition, the biological activity of this new compound on the acetylcholinesterase (AChE) enzyme, an important enzyme for the nervous system, was investigated. When the infrared (IR) spectrum of the complex is examined, the OH vibration peak resulting from HO molecules in the structure at 3948-3337 cm and at 2138 cm, along with a CN peak coordinated to Ag, can be seen, indicating that the mass remaining in the thermal degradation of the complex at 1000 ◦ C is the weight corresponding to the metal mixture consisting of K+Ag (calc.: 68.06). The crystal method revealed that the complex has a sandwich-like, polymeric chemical structure with layers formed by K cations and [Ag(CN)HO] anions. Therefore, the AChE enzyme has potential therapeutic uses in improving ACh levels in brain cells, in reducing various side effects, and in improving cognitive impairment, especially in advanced Alzheimer's disease patients. In this study, the activity of this newly synthesized complex on AChE was also investigated. As a result of this research, [Ag(CN)(HO)K] had 0.0282 ± 0.010 μM Ki values against AChE. The compound was therefore a good inhibitor for the AChE enzyme. This type of compound can be used for the development of novel anticholinesterase drugs.

摘要

含氰化亚银(I)的配位化合物因其具有抗菌、抗真菌、抗生物膜和抗癌等治疗特性而具有显著的生物潜力。在本研究中,合成了一种基于氰化亚银(I)的新型配合物,并通过各种程序(元素分析、热分析、配合物的傅里叶变换红外光谱)进行表征,其中包括对该配合物的晶体分析。此外,还研究了这种新化合物对乙酰胆碱酯酶(AChE)的生物活性,乙酰胆碱酯酶是神经系统的一种重要酶。当检查该配合物的红外(IR)光谱时,可以看到结构中HO分子在3948 - 3337 cm以及2138 cm处产生的OH振动峰,以及与Ag配位的CN峰,这表明在1000℃热降解时配合物剩余的质量是对应于由K + Ag组成的金属混合物的重量(计算值:68.06)。晶体学方法表明,该配合物具有类似三明治的聚合物化学结构,由K阳离子和[Ag(CN)HO]阴离子形成层状结构。因此,AChE酶在提高脑细胞中乙酰胆碱水平、减少各种副作用以及改善认知障碍方面具有潜在的治疗用途,尤其是在晚期阿尔茨海默病患者中。在本研究中,还研究了这种新合成的配合物对AChE的活性。这项研究的结果表明,[Ag(CN)(HO)K]对AChE的Ki值为0.0282±0.010μM。因此,该化合物是AChE酶的良好抑制剂。这类化合物可用于开发新型抗胆碱酯酶药物。

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