雌激素受体α（ERα）和β（ERβ）：亚型选择性配体及临床潜力。
Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.
作者信息
Paterni Ilaria, Granchi Carlotta, Katzenellenbogen John A, Minutolo Filippo
机构信息
Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Department of Chemistry, University of Illinois, 600 S. Mathews Avenue, Urbana, IL 61801, USA.
出版信息
Steroids. 2014 Nov;90:13-29. doi: 10.1016/j.steroids.2014.06.012. Epub 2014 Jun 24.
Abstract
Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are involved in the regulation of many complex physiological processes in humans. Modulation of these receptors by prospective therapeutic agents is currently being considered for prevention and treatment of a wide variety of pathological conditions, such as, cancer, metabolic and cardiovascular diseases, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update of compounds that have been recently reported as modulators of ERs, with a particular focus on their potential clinical applications.
摘要
雌激素受体α（ERα）和β（ERβ）是核转录因子，参与人类许多复杂生理过程的调节。目前正在考虑使用前瞻性治疗药物对这些受体进行调节，以预防和治疗多种病理状况，如癌症、代谢性疾病和心血管疾病、神经退行性变、炎症以及骨质疏松症。本综述概述并更新了最近报道的作为雌激素受体调节剂的化合物，特别关注它们的潜在临床应用。
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