Buchelnikov Anatoly S, Evstigneev Maxim P
Department of Biology and Chemistry, Belgorod State University, Belgorod 308015, Russia.
Department of Biology and Chemistry, Belgorod State University, Belgorod 308015, Russia; Department of Physics, Sevastopol National Technical University, Sevastopol 299053, Russia.
J Theor Biol. 2014 Sep 21;357:268-71. doi: 10.1016/j.jtbi.2014.06.016. Epub 2014 Jun 24.
According to the theory of interceptor-protector action a quantitative link between the physico-chemical parameters of molecular complexation and in vitro biological effect in aromatic drug-interceptor systems must exist. In the present communication such link between relative change in mutagenicity of IQ-type aromatic mutagens on addition of aromatic interceptor molecules with equilibrium hetero-association constants of mutagen-interceptor complexation has been found using the published in vitro data in bacteria cell systems.
根据拦截-保护作用理论，在芳香族药物-拦截剂体系中，分子络合的物理化学参数与体外生物学效应之间必然存在定量联系。在本通讯中，利用已发表的细菌细胞体系体外数据，发现了IQ型芳香族诱变剂在添加芳香族拦截剂分子后诱变性的相对变化与诱变剂-拦截剂络合的平衡异质缔合常数之间的这种联系。
