Chan H K, Gonda I
Department of Pharmacy, University of Sydney, NSW, Australia.
J Pharm Sci. 1989 Feb;78(2):176-80. doi: 10.1002/jps.2600780221.
Respirable crystals of cromoglycic acid (CA) were prepared by precipitation of CA with hydrochloric acid from aqueous solutions of cromolyn sodium and subsequent recrystallization from hot water or mixtures of dimethyl sulphoxide and water. The properties of the materials were established by melting point measurements, UV, IR, and NMR spectroscopy, and X-ray diffraction. Aerosols of CA were generated by nebulization of dilute CA suspensions and drying. The aerodynamic size distribution of CA in the dried aerosols was found by cascade impaction, and could be characterized by a logarithmic normal function with a mass median aerodynamic diameter (MMAD) of 0.7 micron and geometric standard deviation (sigma g) of 1.9. The likely advantages and problems of CA aerosols in the prevention of asthma are discussed.
通过用盐酸从色甘酸钠水溶液中沉淀出色甘酸（CA），随后从热水或二甲基亚砜与水的混合物中重结晶，制备了可吸入的色甘酸晶体。通过熔点测量、紫外、红外和核磁共振光谱以及X射线衍射确定了材料的性质。通过雾化稀释的CA悬浮液并干燥来产生CA气雾剂。通过多级冲击法测定干燥气雾剂中CA的空气动力学粒径分布，其特征可用质量中值空气动力学直径（MMAD）为0.7微米、几何标准差（σg）为1.9的对数正态函数来描述。讨论了CA气雾剂在预防哮喘方面可能的优点和问题。
