Chan H K, Gonda I
Department of Pharmacy, University of Sydney, NSW, Australia.
J Pharm Sci. 1995 Jun;84(6):692-6. doi: 10.1002/jps.2600840606.
Elongated, respirable particles of nedocromil were prepared by its crystallization from N-methyl-2-pyrrolidone (NMP) obtained from an aqueous solution of its sodium salt by precipitation with hydrochloric acid. Aerosols of these particles were recently generated and characterized for their aerodynamic properties (Chan, H.-K.; Gonda, I. J. Aerosol Med. 1993, 6, 241-249). This paper reports the physiochemical properties of the solid form of nedocromil as characterized by polarizing optical and scanning electron microscopies, thermal analysis (DSC, TGA), X-ray powder diffraction, water vapor adsorption isotherms, mass spectrometry, solid state Fourier transform IR and solution 1H-NMR spectroscopies.
通过将奈多罗米从其钠盐的水溶液中用盐酸沉淀得到的N-甲基-2-吡咯烷酮（NMP）中结晶，制备出了细长的、可吸入的奈多罗米颗粒。最近制备了这些颗粒的气雾剂，并对其空气动力学性质进行了表征（Chan，H.-K.；Gonda，I.《气溶胶医学杂志》1993年，6卷，241 - 249页）。本文报道了通过偏光光学显微镜和扫描电子显微镜、热分析（DSC、TGA）、X射线粉末衍射、水蒸气吸附等温线、质谱、固态傅里叶变换红外光谱和溶液1H-NMR光谱表征的奈多罗米固体形式的物理化学性质。
