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贲门失弛缓症治疗中的争议

Controversies in management of achalasia.

作者信息

Patti Marco G, Fisichella Piero M

机构信息

Department of Surgery, Center for Esophageal Diseases, Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 5095, Room G-207, Chicago, IL, 60637, USA,

出版信息

J Gastrointest Surg. 2014 Sep;18(9):1705-9. doi: 10.1007/s11605-014-2556-7. Epub 2014 Jun 28.

Abstract

BACKGROUND

Esophageal achalasia is a primary motility disorder of unknown etiology. It is characterized by lack of esophageal peristalsis and failure of the lower esophageal sphincter to relax appropriately in response to swallowing. The goal of treatment is to improve esophageal emptying and patient's symptoms by decreasing the functional obstruction at the level of the gastroesophageal junction. This can be accomplished by either endoscopic modalities (intra-sphincteric injection of botulinum toxin, pneumatic dilatation, per oral endoscopic myotomy) or by a laparoscopic Heller myotomy.

RESULTS

Review of the current literature suggests that a laparoscopic Heller myotomy should be considered today the primary form of treatment for achalasia and recommends a treatment algorithm for this disease.

摘要

背景

食管贲门失弛缓症是一种病因不明的原发性动力障碍性疾病。其特征为食管蠕动缺失以及食管下括约肌在吞咽时不能适当松弛。治疗目标是通过减轻胃食管交界处的功能性梗阻来改善食管排空及患者症状。这可通过内镜治疗方式(内镜下括约肌内注射肉毒杆菌毒素、气囊扩张、经口内镜下肌切开术)或腹腔镜下Heller肌切开术来实现。

结果

对当前文献的回顾表明,腹腔镜下Heller肌切开术如今应被视为贲门失弛缓症的主要治疗方式,并为此疾病推荐了一种治疗方案。

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