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一种通过碱催化的一锅三组分反应将嘧啶环合到甾体和非甾体化合物上的有效途径。

An efficient route for annulation of pyrimidines to steroids and non-steroids via a base catalyzed one-pot three component reaction.

作者信息

Saikia Pallabi, Gogoi Shyamalee, Gogoi Sanjib, Boruah Romesh C

机构信息

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.

出版信息

Steroids. 2014 Oct;88:1-6. doi: 10.1016/j.steroids.2014.06.015. Epub 2014 Jun 25.

DOI:10.1016/j.steroids.2014.06.015
PMID:24973635
Abstract

A facile strategy for the synthesis of steroidal A- and D-ring fused pyrimidines has been accomplished in high yields via a one-pot reaction of steroidal ketones, aromatic aldehydes and amidine derivatives in presence of potassium tert-butoxide in refluxing ethanol. The generality of the reaction was also extended to non-steroidal ketones.

摘要

通过甾体酮、芳香醛和脒衍生物在叔丁醇钾存在下于回流乙醇中进行一锅反应，已实现了一种简便的合成甾体A环和D环稠合嘧啶的策略，产率很高。该反应的通用性还扩展到了非甾体酮。

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引用本文的文献

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Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells.甾体嘧啶和二氢三嗪作为针对激素依赖性乳腺癌细胞的新型抗癌剂。
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