通过一锅三步缩合反应合成高取代的 4H-吡啶并[1,2-a]嘧啶。
Synthesis of highly substituted 4H-pyrido[1,2-a]pyrimidines via a one-pot three-component condensation reaction.
机构信息
The Center for Combinatorial Chemistry and Drug Discovery, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University , 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
出版信息
ACS Comb Sci. 2013 Sep 9;15(9):519-24. doi: 10.1021/co400086u. Epub 2013 Aug 22.
PMID:23914724
Abstract
A one-pot three-component reaction, involving condensation of 2-aminopyridines, aldehydes, and ketones/aldehydes under trifluoromethanesulfonic acid catalysis, provides rapid access to highly substituted novel 4H-pyrido[1,2-a]pyrimidines.
摘要
一锅法三组分反应，在三氟甲磺酸催化下，由 2-氨基吡啶、醛和酮/醛缩合而成，为高度取代的新型 4H-吡啶并[1,2-a]嘧啶的快速合成提供了途径。
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