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从鱼缸到癌症治疗床边:对伦纳德·宗的采访

From fish tank to bedside in cancer therapy: an interview with Leonard Zon.

作者信息

Zon Leonard, Cagan Ross

出版信息

Dis Model Mech. 2014 Jul;7(7):735-8. doi: 10.1242/dmm.016642.

Abstract

Leonard Zon, who is based at Harvard Medical School, is internationally recognized for his pioneering work in hematology and stem cell biology. His lab uses zebrafish as a model to understand blood cell development and, in recent years, has made inspiring breakthroughs in the treatment of blood diseases and cancer, helping to establish zebrafish as a powerful model for translational research. In this interview, Leonard speaks to Disease Models & Mechanisms Editor-in-Chief, Ross Cagan, about the evolution of his career from developmental biologist to physician-scientist and the stories behind some of his major research accomplishments. He also discusses challenges and opportunities in zebrafish research and provides advice on translating basic research findings to the clinic.

摘要

伦纳德·宗就职于哈佛医学院,他在血液学和干细胞生物学领域的开创性工作在国际上广受认可。他的实验室以斑马鱼为模型来研究血细胞发育,近年来,在血液疾病和癌症治疗方面取得了鼓舞人心的突破,助力斑马鱼成为转化研究的有力模型。在本次访谈中,伦纳德与《疾病模型与机制》主编罗斯·卡根探讨了他从发育生物学家转变为医学科学家的职业发展历程,以及他一些重大研究成果背后的故事。他还讨论了斑马鱼研究中的挑战与机遇,并就将基础研究成果转化至临床提供了建议。

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