Breyer Matthew D, Look A Thomas, Cifra Alessandra
Eli Lilly and Company, Indianapolis, IN 46285, USA
Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 01864, USA
Dis Model Mech. 2015 Oct 1;8(10):1171-4. doi: 10.1242/dmm.023036.
Model systems, including laboratory animals, microorganisms, and cell- and tissue-based systems, are central to the discovery and development of new and better drugs for the treatment of human disease. In this issue, Disease Models & Mechanisms launches a Special Collection that illustrates the contribution of model systems to drug discovery and optimisation across multiple disease areas. This collection includes reviews, Editorials, interviews with leading scientists with a foot in both academia and industry, and original research articles reporting new and important insights into disease therapeutics. This Editorial provides a summary of the collection's current contents, highlighting the impact of multiple model systems in moving new discoveries from the laboratory bench to the patients' bedsides.
模型系统，包括实验动物、微生物以及基于细胞和组织的系统，对于发现和开发用于治疗人类疾病的更新、更好的药物至关重要。在本期中，《疾病模型与机制》推出了一个专题合集，展示了模型系统在多个疾病领域对药物发现和优化的贡献。该合集包括综述、社论、对学术界和工业界都有涉足的顶尖科学家的访谈，以及报道疾病治疗新的重要见解的原创研究文章。这篇社论总结了该合集的当前内容，强调了多种模型系统在将新发现从实验室工作台推向患者床边方面的影响。
