Etlin Alex, Finkel Eran, Cherniak Meir, Lev-Tov Aharon, Anglister Lili
Department of Medical Neurobiology, IMRIC, The Hebrew University Medical School, Jerusalem, 9112102, Israel.
J Mol Neurosci. 2014 Jul;53(3):517-24. doi: 10.1007/s12031-014-0351-2. Epub 2014 Jun 29.
Cholinergic networks have been shown to be involved in generation and modulation of the locomotor rhythmic pattern produced by the mammalian central pattern generators. Here, we show that changes in the endogenous levels of acetylcholine in the sacral segments of the isolated spinal cord of the neonatal rat modulate the locomotor-related output produced by stimulation of sacrocaudal afferents in muscarinic receptor-dependent mechanisms. Cholinergic components we found on sacral relay neurons with lumbar projections through the ventral and lateral funiculi are suggested to mediate this ascending cholinergic modulation. Our findings, possible mechanisms accounting for them, and their potential implications are discussed.
胆碱能网络已被证明参与哺乳动物中枢模式发生器产生的运动节律模式的生成和调节。在此，我们表明，新生大鼠离体脊髓骶段内源性乙酰胆碱水平的变化，通过毒蕈碱受体依赖性机制调节骶尾传入神经刺激所产生的与运动相关的输出。我们在通过腹侧和外侧索具有腰段投射的骶中继神经元上发现的胆碱能成分，被认为介导了这种上行胆碱能调节。我们讨论了我们的发现、解释这些发现的可能机制及其潜在意义。
