肾移植中的巨噬细胞：作用和治疗意义。
Macrophages in renal transplantation: Roles and therapeutic implications.
机构信息
Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia.
Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia.
出版信息
Cell Immunol. 2014 Sep-Oct;291(1-2):58-64. doi: 10.1016/j.cellimm.2014.05.009. Epub 2014 Jun 14.
The presence of macrophages within transplanted renal allografts has been appreciated for some time, whereby macrophages were viewed primarily as participants in the process of cell-mediated allograft rejection. Recent insights into macrophage biology have greatly expanded our conceptual understanding of the multiple roles of macrophages within the allograft. Distinct macrophage subsets are present within the kidney and these sub-serve discrete functions in promoting and attenuating inflammation, immune modulation and tissue repair. Unraveling the complex roles macrophages play in transplantation will allow identification of potential therapeutic targets to prevent and treat allograft rejection and maximize graft longevity.
一段时间以来，人们已经意识到巨噬细胞存在于移植的肾脏同种异体移植物中，巨噬细胞主要被视为细胞介导的同种异体移植物排斥反应过程的参与者。最近对巨噬细胞生物学的深入了解极大地扩展了我们对巨噬细胞在同种异体移植物中多种作用的概念理解。肾脏中存在着不同的巨噬细胞亚群，这些亚群在促进和减轻炎症、免疫调节和组织修复方面发挥着不同的作用。揭示巨噬细胞在移植中的复杂作用将有助于确定潜在的治疗靶点，以预防和治疗移植物排斥反应，最大限度地延长移植物的寿命。
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