Silveri Maria Caterina, Pravatà Emanuele, Brita Anna Clelia, Improta Erika, Ciccarelli Nicoletta, Rossi Paola, Colosimo Cesare
Medicine of the Ageing, Department of Geriatrics, Neuroscience and Orthopedics, Italy.
Department of Neuroimaging, Catholic University, Roma, Italy.
Brain Lang. 2014 Aug;135:57-65. doi: 10.1016/j.bandl.2014.05.004. Epub 2014 Jun 27.
We investigated whether primary progressive aphasias (PPA) reflect non-random degradation of linguistic dimensions that might be supported by different neural subsystems and to what extent this degradation contributes to the emergence of clinical entities: semantic (S), logopenic (L) and nonfluent (NF) aphasia; apraxia of speech was also considered if associated with language disorders (AOS/aph). Forty-two aphasic patients are reported. Two main definable patterns of linguistic deficits tended to emerge that corresponded with identifiable patterns of brain atrophy, and probably diseases: the S variant, which principally expresses the impact of a "deep" cognitive (semantic) disorder on language, and AOS/aph in which "peripheral" executive components play a significant role. By contrast, NF aphasia emerged as a heterogeneous variant due to disorganization of various dimensions within the linguistic domain, that assumes different patterns depending on the differential distribution of atrophy in the perisylvian regions.
我们研究了原发性进行性失语（PPA）是否反映了可能由不同神经子系统支持的语言维度的非随机退化，以及这种退化在多大程度上导致了临床实体的出现：语义性（S）、音韵性（L）和非流利性（NF）失语；如果与语言障碍相关（言语失用/失语，AOS/aph），也考虑言语失用。报告了42例失语患者。两种主要的可定义语言缺陷模式倾向于出现，它们与可识别的脑萎缩模式以及可能的疾病相对应：S型变体，主要表现为“深层”认知（语义）障碍对语言的影响，以及AOS/aph，其中“外周”执行成分起重要作用。相比之下，NF失语是一种异质性变体，是由于语言领域内各个维度的紊乱所致，其模式因颞周区域萎缩的不同分布而异。
