Grossman Murray, Irwin David J
Continuum (Minneap Minn). 2018 Jun;24(3, BEHAVIORAL NEUROLOGY AND PSYCHIATRY):745-767. doi: 10.1212/CON.0000000000000618.
This article summarizes the clinical and anatomic features of the three named variants of primary progressive aphasia (PPA): semantic variant PPA, nonfluent/agrammatic variant PPA, and logopenic variant PPA. Three stroke aphasia syndromes that resemble the PPA variants (Broca aphasia, Wernicke aphasia, and conduction aphasia) are also presented.
Semantic variant PPA and Wernicke aphasia are characterized by fluent speech with naming and comprehension difficulty; these syndromes are associated with disease in different portions of the left temporal lobe. Patients with nonfluent/agrammatic variant PPA or Broca aphasia have nonfluent speech with grammatical difficulty; these syndromes are associated with disease centered in the left inferior frontal lobe. Patients with logopenic variant PPA or conduction aphasia have difficulty with repetition and word finding in conversational speech; these syndromes are associated with disease in the left inferior parietal lobe. While PPA and stroke aphasias resemble one another, this article also presents their distinguishing features.
Primary progressive and stroke aphasia syndromes interrupt the left perisylvian language network, resulting in identifiable aphasic syndromes.
本文总结了原发性进行性失语（PPA）三种命名变体的临床和解剖学特征：语义变体PPA、非流利/语法缺失变体PPA和音韵性失语变体PPA。还介绍了三种类似于PPA变体的中风失语综合征（布罗卡失语、韦尼克失语和传导性失语）。
语义变体PPA和韦尼克失语的特征是言语流利但存在命名和理解困难；这些综合征与左侧颞叶不同部位的病变有关。非流利/语法缺失变体PPA或布罗卡失语患者的言语不流利且存在语法困难；这些综合征与以左侧额下回为中心的病变有关。音韵性失语变体PPA或传导性失语患者在对话言语中存在重复和找词困难；这些综合征与左侧顶下叶的病变有关。虽然PPA和中风失语症彼此相似，但本文也介绍了它们的区别特征。
原发性进行性和中风失语综合征中断了左侧外侧裂周语言网络，导致可识别的失语综合征。
