小富含谷氨酰胺的 TPR 结构域蛋白 A（SGTA）在非霍奇金淋巴瘤中的表达促进肿瘤增殖并逆转细胞黏附介导的药物耐药性（CAM-DR）。
Expression of small glutamine-rich TPR-containing protein A (SGTA) in Non-Hodgkin's Lymphomas promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR).
机构信息
Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China.
Department of Pathology, Medical College, Nantong University, Nantong 226001, Jiangsu, China.
出版信息
Leuk Res. 2014 Aug;38(8):955-63. doi: 10.1016/j.leukres.2014.05.013. Epub 2014 Jun 2.
The expression and biologic function of SGTA in Non-Hodgkin's Lymphomas (NHL) was investigated in this study. Clinically, by immunohistochemistry analysis we detected SGTA expression in both reactive lymphoid tissues and NHL tissues. In addition, we also correlated high expression of SGTA with poor prognosis. Functionally, SGTA expression was positively related with cell proliferation and negative related with cell adhesion. Finally, SGTA knockdown induced adhesion-mediated drug resistance. Our finding supports a role of SGTA in NHL cell proliferation, adhesion and drug resistance, and it may pave the way for a novel therapeutic approach for CAM-DR in NHL.
本研究旨在探讨 SGTA 在非霍奇金淋巴瘤（NHL）中的表达及其生物学功能。临床上，通过免疫组化分析，我们检测到 SGTA 在反应性淋巴组织和 NHL 组织中均有表达。此外，我们还发现 SGTA 的高表达与预后不良相关。功能上，SGTA 的表达与细胞增殖呈正相关，与细胞黏附呈负相关。最后，SGTA 敲低诱导了黏附介导的耐药性。我们的研究结果支持 SGTA 在 NHL 细胞增殖、黏附和耐药中的作用，为 NHL 中 CAM-DR 的新型治疗方法开辟了道路。
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