Mar'iandyshev A O, Evstaf'ev Iu A, Andreeva L A
Probl Tuberk. 1989(1):34-7.
To estimate the effect of nitroglycerin (NTG) on the external respiration function and central hemodynamics, 124 patients with various forms of pulmonary tuberculosis and chronic nonspecific diseases of the lungs were examined. The indices of the external respiration function, central hemodynamics, pulmonary artery systolic pressure (PASP), general pulmonary resistance (GPR) and blood gaseous composition were determined before and after NTG sublingual use in a dose of 1 mg. It was noted that improvement of bronchial patency after the use of NTG was not significant and subsequently its indication as an agent arresting bronchospasm is not expedient. A statistically significant decrease in PASP and the indices of central hemodynamics, as well as a decrease in GPR might be considered as a basis for the use of nitrates in prophylaxis and treatment of chronic pulmonary heart in patients with pulmonary tuberculosis.
为评估硝酸甘油（NTG）对外呼吸功能和中心血流动力学的影响，对124例患有各种类型肺结核和慢性非特异性肺部疾病的患者进行了检查。在舌下含服1mg NTG前后，测定了外呼吸功能、中心血流动力学、肺动脉收缩压（PASP）、总肺阻力（GPR）和血液气体成分指标。结果发现，使用NTG后支气管通畅性的改善并不显著，因此将其作为缓解支气管痉挛的药物并不适宜。PASP和中心血流动力学指标的统计学显著下降以及GPR的降低，可被视为硝酸盐用于肺结核患者慢性肺心病预防和治疗的依据。
