Zhang Ge, Xu Xin, Su Wei, Xu Qiuping
Southeast Asian J Trop Med Public Health. 2014 May;45(3):736-45.
The relationship between smoking and venous thromboembolism (VTE) is unclear, as a result we conducted a meta-analysis to assess the association between smoking and VTE. A comprehensive search was conducted to identify studies evaluating the relationship between smoking and VTE. Two reviewers independently selected studies and extracted data. The data were analyzed using Comprehensive Meta-Analysis software, version 2. Twenty-one studies were included. Our findings show current smoking (RR 1.24; 95% CI: 1.14-1.35) and former smoking (RR 1.05; 95% CI: 1.01-1.10) were associated with increased VTE risk. There was a dose-response relationship between cigarettes smoked per day and VTE: 1-14 cigarettes/day: RR 1.20; 95% CI: 1.08-1.34, I2 = 0%; 15-24 cigarettes/day: RR 1.33; 95% CI: 1.15-1.54, I2 = 0%; > 25 cigarettes/day: RR 1.63; 95% CI: 1.37-1.95, I2 = 6%. Our findings show smoking is a risk factor for VTE with a dose-response relationship.
吸烟与静脉血栓栓塞症（VTE）之间的关系尚不清楚，因此我们进行了一项荟萃分析，以评估吸烟与VTE之间的关联。我们进行了全面检索，以确定评估吸烟与VTE关系的研究。两名审阅者独立选择研究并提取数据。使用综合荟萃分析软件2对数据进行分析。共纳入21项研究。我们的研究结果显示，当前吸烟（RR 1.24；95%CI：1.14 - 1.35）和既往吸烟（RR 1.05；95%CI：1.01 - 1.10）与VTE风险增加相关。每天吸烟量与VTE之间存在剂量反应关系：每天1 - 14支烟：RR 1.20；95%CI：1.08 - 1.34，I2 = 0%；每天15 - 24支烟：RR 1.33；95%CI：1.15 - 1.54，I2 = 0%；每天超过25支烟：RR 1.63；95%CI：1.37 - 1.95，I2 = 6%。我们的研究结果表明，吸烟是VTE的一个危险因素，且存在剂量反应关系。
