四氯化碳对分离的大鼠肝细胞中花生四烯酸代谢的刺激作用。
Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes.
作者信息
Marinovich M, Flaminio L M, Papagni M, Galli C L
机构信息
Institute of Pharmacological Sciences, Univ. of Milan, Italy.
出版信息
Prostaglandins. 1989 Jan;37(1):23-31. doi: 10.1016/0090-6980(89)90029-4.
PMID:2497498
Abstract
Arachidonic acid metabolism was evaluated in isolated rat hepatocytes after CCl4 exposure. CCl4 induced dose-dependently the synthesis and release of prostacyclin (PGI2) and thromboxane (TXB2). Treatment with prostaglandin E2 (PGE2) 30 min after exposure to CCl4, significantly reduced the cell damage as well as the release of TXB2 from the cells.
摘要
在四氯化碳暴露后，对分离的大鼠肝细胞中的花生四烯酸代谢进行了评估。四氯化碳剂量依赖性地诱导前列环素（PGI2）和血栓素（TXB2）的合成与释放。在暴露于四氯化碳30分钟后用前列腺素E2（PGE2）处理，可显著降低细胞损伤以及细胞中TXB2的释放。
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