Research Centre on Public Health (CESP), University of Milan-Bicocca, Villa Serena, Via Pergolesi 33, I-20052, Monza, Italy; CHARTA Foundation, Milan, Italy.
Br J Dermatol. 2015 Jan;172(1):187-95. doi: 10.1111/bjd.13220. Epub 2014 Nov 21.
Data on the epidemiological impact and clinical characteristics of chronic hand eczema in Southern Europe are lacking.
To estimate the prevalence of chronic hand eczema in its different stages of severity and refractoriness to standard therapy in patients accessing Italian dermatological reference centres, and to evaluate sociodemographic and clinical factors associated with each stage.
A cross-sectional multicentre study was conducted. Adult patients with hand eczema, consecutively accessing 14 centres over a 6-month period, were enrolled. Patients were classified according to disease duration, severity and response to standard therapy with potent topical corticosteroids. Logistical regression was performed to investigate the relationship between sociodemographic and clinical data with different stages of eczema.
The total number of participants was 981. Hand eczema was chronic in 83·5% of patients; 21·3% had severe eczema, with 62·0% of these patients refractory to standard therapy. Food processing and related work, the health professions, craft and related trade works (building, plumbing, electrical), hairdressing/beauty and handicraft work were most frequently associated with chronic hand eczema. Severe chronic hand eczema was more likely to be seen in men, older patients and those with less education. Severe and refractory hand eczema was also more likely among the unemployed and patients with allergic rhinitis and/or atopic dermatitis.
Chronic hand eczema is frequent among patients with hand eczema accessing dermatology centres. Many patients were severe and refractory to standard therapy. The appropriate identification of hand eczema is the first step in implementing effective and efficient treatments.
关于南欧慢性手部湿疹的流行病学影响和临床特征的数据尚不清楚。
评估在意大利皮肤科参考中心就诊的患者中不同严重程度和对抗生素标准治疗的慢性手部湿疹的患病率，并评估与每个阶段相关的社会人口统计学和临床因素。
进行了一项横断面多中心研究。在 6 个月的时间内，连续招募了 14 个中心的患有手部湿疹的成年患者。根据疾病持续时间、严重程度和对强效外用皮质类固醇标准治疗的反应对患者进行分类。使用逻辑回归来研究社会人口统计学和临床数据与湿疹不同阶段之间的关系。
共有 981 名参与者。83.5%的患者手部湿疹为慢性；21.3%的患者患有严重的湿疹，其中 62.0%的患者对抗生素标准治疗有反应。食品加工和相关工作、卫生专业、手工艺和相关贸易工作（建筑、管道、电气）、美发/美容和手工艺工作与慢性手部湿疹最相关。严重的慢性手部湿疹更可能发生在男性、老年患者和受教育程度较低的患者中。失业患者以及患有过敏性鼻炎和/或特应性皮炎的患者更容易出现严重和难治性手部湿疹。
在皮肤科中心就诊的手部湿疹患者中，慢性手部湿疹很常见。许多患者的病情严重且对抗生素标准治疗有反应。正确识别手部湿疹是实施有效和高效治疗的第一步。
