Division of Clinical Social Medicine, University of Heidelberg, Germany.
J Dtsch Dermatol Ges. 2011 Sep;9(9):682-8. doi: 10.1111/j.1610-0387.2011.07694.x. Epub 2011 May 12.
The aim of the CARPE (German acronym: Chronisches Handekzem-Register zum Patienten-Langzeitmanagement; meaning: chronic hand eczema registry on long-term patient management) registry is to investigate characteristics and treatment modalities in patients affected by chronic hand eczema in Germany.
The registry was built up under the auspices of the German Dermatological Society (Deutsche Dermatologische Gesellschaft, DDG). Patients with chronic hand eczema are prospectively assessed by dermatological examination and patient questionnaire. Socio-economic data and data on diagnostics, skin status, severity and treatment of chronic hand eczema and atopy criteria are repeatedly assessed. Here, we present baseline characteristics of the first 515 patients.
53.8 % of the patients were female, mean age was 47.3 years. The average duration of CHE was 7.7 years. 30.4 % had already received inpatient care, 31.2 % had been on sick leave in the past 12 months. 94.5 % had received topical corticosteroids prior to inclusion in the registry, 31.9 % topical calcineurin inhibitors, 38.3 % UV therapy, 28.6 % systemic antihistamines, 36.5 % systemic treatments, 14.9 % systemic corticosteroids, 25.8 % systemic retinoids.
The CARPE project demonstrates the high medical burden and therapeutic challenge of chronic hand eczema and presents first data for health care research. Furthermore, the designed follow-up study will present important data about the natural history and prognosis of this chronic skin disease.
CARPE（德语缩写：Chronisches Handekzem-Register zum Patienten-Langzeitmanagement；意为：慢性手部湿疹患者长期管理登记）的目的是调查德国慢性手部湿疹患者的特征和治疗方式。
该登记由德国皮肤病学会（Deutsche Dermatologische Gesellschaft，DDG）发起。慢性手部湿疹患者通过皮肤科检查和患者问卷调查进行前瞻性评估。社会经济数据以及诊断、皮肤状况、慢性手部湿疹的严重程度和治疗以及过敏标准的数据反复评估。在这里，我们介绍了前 515 名患者的基线特征。
53.8%的患者为女性，平均年龄为 47.3 岁。手部湿疹的平均病程为 7.7 年。30.4%的患者曾接受过住院治疗，31.2%的患者在过去 12 个月请过病假。94.5%的患者在入组前曾接受过局部皮质类固醇治疗，31.9%接受过局部钙调磷酸酶抑制剂治疗，38.3%接受过紫外线治疗，28.6%接受过全身性抗组胺治疗，36.5%接受过全身性治疗，14.9%接受过全身性皮质类固醇治疗，25.8%接受过全身性类视黄醇治疗。
CARPE 项目表明慢性手部湿疹给患者带来了很高的医疗负担和治疗挑战，并提供了医疗保健研究的初步数据。此外，设计的随访研究将提供有关这种慢性皮肤病自然史和预后的重要数据。
