Bujarski Spencer, Roche Daniel J O, Lunny Katy, Moallem Nathasha R, Courtney Kelly E, Allen Vincent, Hartwell Emily, Leventhal Adam, Rohrbaugh Taylor, Ray Lara A
Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Department of Preventive Medicine and Psychology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Drug Alcohol Depend. 2014 Sep 1;142:127-32. doi: 10.1016/j.drugalcdep.2014.06.004. Epub 2014 Jun 17.
While methamphetamine (MA) and alcohol are often used in combination, little is known about the pattern of co-use between these substances. The goal of the present study is to examine the relationship between MA use and alcohol use in a community sample of non-treatment seeking regular MA users.
Participants completed a face-to-face assessment battery, which included a diagnostic interview for MA dependence and the timeline follow-back interview for both alcohol and MA use over the past 30 days. Sixty regular MA and alcohol users supplied data for 1800 person-days.
Compared with non-drinking days, drinking days and binge drinking days increased the odds of same day MA use by 4.22 and 4.50 times, respectively (p's<0.0001). Further, binge drinking incrementally increased risk for MA use above and beyond the effects of drinking itself (p<0.0001). Lagged models revealed previous day MA use to predict following day MA use (p<0.0001), yet, after controlling for this relationship, neither previous day alcohol use nor previous day binge drinking predicted following-day MA use. Finally, the effect of binge drinking on MA use was stronger among individuals with lower MA dependence severity or higher alcohol problem severity (p's<0.05).
These results suggest that alcohol and MA are co-used in predictable patterns, and in particular, that binge drinking may be incrementally associated with the likelihood of MA use. Future studies are needed to explore the temporal relationship between alcohol and MA use within a given episode.
虽然甲基苯丙胺（MA）和酒精经常同时使用，但对于这些物质之间的共同使用模式知之甚少。本研究的目的是在一个未寻求治疗的定期使用MA的社区样本中，研究MA使用与酒精使用之间的关系。
参与者完成了一系列面对面评估，包括对MA依赖的诊断访谈以及对过去30天内酒精和MA使用情况的时间线追溯访谈。60名定期使用MA和酒精的用户提供了1800人日的数据。
与不饮酒日相比，饮酒日和暴饮日当天使用MA的几率分别增加了4.22倍和4.50倍（p值<0.0001）。此外，暴饮除了饮酒本身的影响之外，还会逐步增加使用MA的风险（p<0.0001）。滞后模型显示前一天使用MA可预测第二天使用MA（p<0.0001），然而，在控制了这种关系之后，前一天的酒精使用和前一天的暴饮都不能预测第二天的MA使用情况。最后，在MA依赖严重程度较低或酒精问题严重程度较高的个体中，暴饮对MA使用的影响更强（p值<0.05）。
这些结果表明，酒精和MA以可预测的模式共同使用，特别是暴饮可能与使用MA的可能性逐步相关。未来需要进行研究，以探索在特定时间段内酒精和MA使用之间的时间关系。
