Teubner Daniel, Kiesslich Ralf, Matsumoto Takayuki, Rey Johannes W, Hoffman Arthur
Department for Internal Medicine, Gastroenterology and Oncology, St Marienkrankenhaus, Richard-Wagner-Street, 14, Frankfurt 60318, Germany.
Department for Internal Medicine, Gastroenterology and Oncology, St Marienkrankenhaus, Richard-Wagner-Street, 14, Frankfurt 60318, Germany.
Gastrointest Endosc Clin N Am. 2014 Jul;24(3):427-34. doi: 10.1016/j.giec.2014.03.012.
Endomicroscopy is a new imaging tool for gastrointestinal endoscopy. In vivo histology becomes possible at subcellular resolution during ongoing colonoscopy. Panchromoendoscopy with targeted biopsies has become the method of choice for surveillance of patients with inflammatory bowel disease. Endomicroscopy can be added after chromoendoscopy to clarify whether standard biopsies are needed. This smart biopsy concept can increase the diagnostic yield of intraepithelial neoplasia and substantially reduce the need for biopsies. Clinical acceptance is increasing because of a multitude of positive studies about the diagnostic value of endomicroscopy. Smart biopsies, functional imaging, and molecular imaging may represent the future for endomicroscopy.
内镜显微镜检查是一种用于胃肠内镜检查的新型成像工具。在进行结肠镜检查时，可在亚细胞分辨率下实现体内组织学检查。采用靶向活检的全色内镜检查已成为炎症性肠病患者监测的首选方法。可在色素内镜检查后加做内镜显微镜检查，以明确是否需要进行标准活检。这种智能活检概念可提高上皮内瘤变的诊断率，并大幅减少活检需求。由于大量关于内镜显微镜检查诊断价值的阳性研究，其临床接受度正在提高。智能活检、功能成像和分子成像可能代表着内镜显微镜检查的未来。
