Rubio Carlos A, Slezak Premysl
Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm 17176, Sweden.
Department of Gastrointestinal Endoscopy, Karolinska University Hospital, Stockholm 17176, Sweden.
Gastrointest Endosc Clin N Am. 2014 Jul;24(3):455-68. doi: 10.1016/j.giec.2014.03.009.
Patients with inflammatory bowel disease may develop dysplasia in the cryptal epithelium, polypoid neoplasias, and nonpolypoid (flat) adenomas, lesions at risk to proceed to colorectal carcinoma. The onset of invasion in nonpolypoid adenomas may occur without changes in the shape or the size of the lesion. In experimental animals, some colonotropic carcinogens induce polypoid and nonpolypoid neoplasias and others induce polypoid neoplasias exclusively. Some of the biologic attributes of nonpolypoid adenomas in humans can be demonstrated in laboratory animals.
炎症性肠病患者可能会在隐窝上皮出现发育异常、息肉样肿瘤和非息肉样（扁平）腺瘤，这些病变有发展为结直肠癌的风险。非息肉样腺瘤的侵袭性发作可能在病变的形状或大小没有改变的情况下发生。在实验动物中，一些亲结肠致癌物会诱发息肉样和非息肉样肿瘤，而其他致癌物则仅诱发息肉样肿瘤。人类非息肉样腺瘤的一些生物学特性可以在实验动物中得到证实。
