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Ballooned hepatocytes, undead cells, sonic hedgehog, and vitamin E: therapeutic implications for nonalcoholic steatohepatitis.

作者信息

Hirsova Petra, Gores Gregory J

机构信息

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

出版信息

Hepatology. 2015 Jan;61(1):15-7. doi: 10.1002/hep.27279. Epub 2014 Nov 20.

DOI:10.1002/hep.27279
PMID:24975580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4277507/
Abstract
摘要

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Reply.回复。
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本文引用的文献

1
Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity.PIVENS试验中的治疗反应与刺猬信号通路活性降低相关。
Hepatology. 2015 Jan;61(1):98-107. doi: 10.1002/hep.27235. Epub 2014 Aug 25.
2
Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis.维莫德吉抑制 TRAIL 介导的非酒精性脂肪性肝炎小鼠模型中的肝损伤。
PLoS One. 2013 Jul 22;8(7):e70599. doi: 10.1371/journal.pone.0070599. Print 2013.
3
The Hedgehog signal transduction network.刺猬信号转导网络。
Sci Signal. 2012 Oct 16;5(246):re6. doi: 10.1126/scisignal.2002906.
4
Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium. hedgehog 诱导的趋化作用是由位于初级纤毛外的 smoothened 介导的。
Sci Signal. 2012 Aug 21;5(238):ra60. doi: 10.1126/scisignal.2002798.
5
Mechanisms of disease progression in NASH: new paradigms.非酒精性脂肪性肝炎（NASH）疾病进展的机制：新范式。
Clin Liver Dis. 2012 Aug;16(3):549-65. doi: 10.1016/j.cld.2012.05.002.
6
A hedgehog survival pathway in 'undead' lipotoxic hepatocytes.刺猬在“不死”脂毒性肝细胞中的生存途径。
J Hepatol. 2012 Oct;57(4):844-51. doi: 10.1016/j.jhep.2012.05.011. Epub 2012 May 26.
7
Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential.刺猬抑制剂获皮肤癌领域里程碑式批准，但在更广泛应用潜力方面仍存在疑问。
Nat Rev Drug Discov. 2012 Mar 30;11(4):257-8. doi: 10.1038/nrd3714.
8
Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease.Hedgehog 通路的激活与人类非酒精性脂肪性肝病的组织学损伤和纤维化严重程度平行。
Hepatology. 2012 Jun;55(6):1711-21. doi: 10.1002/hep.25559. Epub 2012 Apr 18.
9
Programmed cell death in animal development and disease.动物发育和疾病中的细胞程序性死亡。
Cell. 2011 Nov 11;147(4):742-58. doi: 10.1016/j.cell.2011.10.033.
10
Increased production of sonic hedgehog by ballooned hepatocytes.气球样肝细胞中 sonic hedgehog 的产量增加。
J Pathol. 2011 Jul;224(3):401-10. doi: 10.1002/path.2888. Epub 2011 May 5.