线粒体靶向诊疗剂的设计、合成及生物学评价
Design, synthesis and biological evaluation of mitochondria targeting theranostic agents.
作者信息
Wu Song, Cao Qizhen, Wang Xiaolin, Cheng Kai, Cheng Zhen
机构信息
Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, California, 94305-5344, USA.
出版信息
Chem Commun (Camb). 2014 Aug 18;50(64):8919-22. doi: 10.1039/c4cc03296a.
PMID:24976119
Abstract
Dual mitochondria targeting fluorescent F16-TPP analogues were designed and synthesized. Uptake and cytotoxicity studies indicate that FF16 and FF16-TPP, two compounds discovered in this study, are promising mitochondria targeting theranostic agents.
摘要
设计并合成了双线粒体靶向荧光F16-TPP类似物。摄取和细胞毒性研究表明，本研究中发现的两种化合物FF16和FF16-TPP是有前景的线粒体靶向诊疗试剂。
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