Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands.
J Invest Dermatol. 2010 Jul;130(7):1807-12. doi: 10.1038/jid.2010.58. Epub 2010 Mar 25.
Epidemiology of rare cutaneous malignancies in the general population is poorly documented. This descriptive study aimed to estimate the incidence and trends of all skin malignancies between 1989 and 2005. Data on skin tumors were extracted from the Netherlands Cancer registry (except for basal cell carcinoma (BCC) data-only available from Comprehensive Cancer Centre South) and categorized according to the International Classification of Diseases for Oncology, third edition, codes. Age-standardized incidence rates (European standardized population rate, ESR) per 100,000 person-years were calculated per year and for the period between 2001 and 2005. Estimated annual percentage changes (EAPCs) were estimated by Poisson regression models. A total of 356,620 skin tumors were diagnosed between 1989 and 2005. Excluding BCC, squamous cell carcinoma (SCC), and melanoma, the remaining skin tumors constituted about 2% of all skin malignancies. The incidence of melanoma showed the steepest increase (EAPC, 4.0%), and ESR was close to that observed for SCC (EAPC, 2.3%) between 2001 and 2005 (17.1 versus 19.6). Hematolymphoid tumors (ESR=0.74) were mainly cutaneous T-cell lymphomas (60.8%). No significant increases in incidence were observed for lymphomas, and appendageal, fibromatous, and myomatous carcinomas during 1989-2005. In addition to keratinocytic cancers and melanoma, there is a wide variety of skin tumors that constitute <2% of all skin malignancies. The incidence of UV-related skin tumors increased significantly and more steeply than did those of other skin malignancies.
在普通人群中，罕见皮肤恶性肿瘤的流行病学资料记载甚少。本描述性研究旨在评估 1989 年至 2005 年间所有皮肤恶性肿瘤的发病率和趋势。皮肤肿瘤数据从荷兰癌症登记处（基底细胞癌（BCC）的数据除外，仅从综合性癌症中心南部获得）提取，并根据国际肿瘤疾病分类，第三版，代码进行分类。每年和 2001 年至 2005 年期间每 100,000 人年计算年龄标准化发病率（欧洲标准化人口率，ESR）。通过泊松回归模型估计估计每年的百分比变化（EAPC）。1989 年至 2005 年间共诊断出 356,620 例皮肤肿瘤。不包括 BCC、鳞状细胞癌（SCC）和黑色素瘤，其余皮肤肿瘤占所有皮肤恶性肿瘤的 2%左右。黑色素瘤的发病率增长最快（EAPC，4.0%），2001 年至 2005 年间 ESR 接近 SCC（EAPC，2.3%）（17.1 比 19.6）。血液淋巴肿瘤（ESR=0.74）主要为皮肤 T 细胞淋巴瘤（60.8%）。1989-2005 年间，未观察到淋巴瘤和附属器、纤维瘤和肌瘤癌的发病率显著增加。除角质形成细胞癌和黑色素瘤外，还有多种皮肤肿瘤，占所有皮肤恶性肿瘤的 2%以下。与紫外线有关的皮肤肿瘤的发病率显著增加，且比其他皮肤恶性肿瘤增加得更为陡峭。
