Jung Eun-Soo, Park Soo-Hyun, Choi Eun-Kyung, Ryu Beun-Ho, Park Byung-Hyun, Kim Dal-Sik, Kim Young-Gon, Chae Soo-Wan
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonbuk, Republic of Korea.
Doul Farming Corporation, Namhae Gohyun Chamyeon, Kyungnam, Republic of Korea.
Nutrition. 2014 Sep;30(9):1034-9. doi: 10.1016/j.nut.2014.02.014. Epub 2014 Mar 12.
The cholesterol-lowering effects of garlic as part of a healthy diet remain controversial. The aim of this study was to investigate whether supplementation with aged black garlic (ABG) could improve blood lipid profiles in patients with mild hypercholesterolemia.
We conducted a double-blind, randomized placebo-controlled trial. Sixty participants were randomly assigned to receive either ABG or placebo twice daily (total 6 g/d) before consumption of a meal every morning and evening for 12 wk. During the study, two participants dropped out of the ABG group, and three participants dropped out of the placebo group. Thus, the effects of AGB on fasting blood levels of lipids were evaluated in 28 participants and compared with the placebo group (n = 27).
Among lipid components, no significant differences in triglycerides, low-density lipoprotein cholesterol, total cholesterol, or free fatty acid levels were observed between the two groups. However, ABG increased high-density lipoprotein cholesterol levels compared with the placebo group at the end of the study. Moreover, a significant decrease in the levels of alipoprotein B and a significant increase in the ratio of low-density lipoprotein cholesterol/alipoprotein B were observed in the ABG group. No adverse effects were reported in any of the patients.
ABG supplementation reduced atherogenic markers and thus may have a cardioprotective effect beyond the gold standard medication in patients with mild hypercholesterolemia.
大蒜作为健康饮食的一部分，其降胆固醇作用仍存在争议。本研究旨在调查补充陈酿黑蒜（ABG）是否能改善轻度高胆固醇血症患者的血脂谱。
我们进行了一项双盲、随机、安慰剂对照试验。60名参与者被随机分配，每天早晚餐前两次分别接受ABG或安慰剂（总量6克/天），持续12周。在研究期间，ABG组有两名参与者退出，安慰剂组有三名参与者退出。因此，在28名参与者中评估了AGB对空腹血脂水平的影响，并与安慰剂组（n = 27）进行比较。
在脂质成分中，两组之间甘油三酯、低密度脂蛋白胆固醇、总胆固醇或游离脂肪酸水平未观察到显著差异。然而，在研究结束时，与安慰剂组相比，ABG使高密度脂蛋白胆固醇水平升高。此外，ABG组中载脂蛋白B水平显著降低，低密度脂蛋白胆固醇/载脂蛋白B比值显著升高。所有患者均未报告不良反应。
补充ABG可降低致动脉粥样硬化标志物水平，因此对于轻度高胆固醇血症患者，可能具有超越金标准药物的心脏保护作用。
