Department of General Internal Medicine, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Beijing University of Chinese Medicine, Beijing, China.
BMC Complement Med Ther. 2023 Jul 22;23(1):260. doi: 10.1186/s12906-023-04038-0.
Garlic (Allium sativum), the underground bulb of the Allium genus, has been consumed on Earth for thousands of years. Many clinical trials of garlic supplementation on components of metabolic syndrome (MetS) have emerged in recent years, but there is no consensus on the effect. This meta-analysis aimed at systematically evaluating the effect of garlic supplementation on components of MetS.
In this meta-analysis, we searched Pubmed, Embase, Cochrane, Medline, Web of Science databases, and clinical trials online sites from inception to November 1, 2022, with language restrictions to English. We engaged participants > 18 years and eligible for the clinical diagnosis of MetS or those with metabolic disorders and garlic was the only intervention. Outcomes included waist circumference, and body mass index, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, blood pressure, and fasting blood glucose. Meta-regression and subgroup analyses were conducted based on six covariates (total sample size, the mean age, the mean dose, the duration of intervention, the oral form of garlic, and the dietary intervention).
Results from 19 RCTs were included engaging 999 participants. Compared to placebo, garlic significantly reduced TG [SMD (95%CI) = -0.66 (-1.23, -0.09)], TC [SMD (95%CI) = -0.43 (-0.86, -0.01)], LDL [SMD (95%CI) = -0.44(-0.88, -0.01)], DBP [SMD (95%CI) = -1.33 (-2.14, -0.53)], BMI [SMD (95%CI) = -1.10(-1.90, -0.20)], and WC [SMD (95%CI) = -0.78(-1.09, -0.47)]. Meta-regression showed age and sample size are potential effect modifiers.
According to the results of meta-analysis, the modulatory effect of garlic on some MetS components is evident. More high-quality, large-scale RCTs are needed to confirm iat based on the high heterogeneity and potential publication bias of the current data.
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=373228 , ID: CRD42022373228.
大蒜（Allium sativum），葱属的地下鳞茎，在地球上已经被食用了数千年。近年来，出现了许多关于大蒜补充剂对代谢综合征（MetS）成分的临床试验，但对于其效果尚无共识。本荟萃分析旨在系统评估大蒜补充剂对 MetS 成分的影响。
在这项荟萃分析中，我们检索了 Pubmed、Embase、Cochrane、Medline、Web of Science 数据库以及临床试验在线网站，检索时间截至 2022 年 11 月 1 日，语言限制为英语。我们纳入了年龄大于 18 岁且符合 MetS 临床诊断或存在代谢紊乱的参与者，且仅接受大蒜干预。结局包括腰围和体重指数、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血压和空腹血糖。根据六个协变量（总样本量、平均年龄、平均剂量、干预持续时间、大蒜的口服形式和饮食干预）进行了荟萃回归和亚组分析。
纳入了 19 项 RCT 共 999 名参与者。与安慰剂相比，大蒜显著降低了甘油三酯[SMD（95%CI）=-0.66（-1.23，-0.09）]、总胆固醇[SMD（95%CI）=-0.43（-0.86，-0.01）]、低密度脂蛋白胆固醇[SMD（95%CI）=-0.44（-0.88，-0.01）]、舒张压[SMD（95%CI）=-1.33（-2.14，-0.53）]、体重指数[SMD（95%CI）=-1.10（-1.90，-0.20）]和腰围[SMD（95%CI）=-0.78（-1.09，-0.47）]。荟萃回归显示年龄和样本量是潜在的效应修饰因子。
根据荟萃分析的结果，大蒜对一些 MetS 成分的调节作用是明显的。需要更多高质量、大规模的 RCT 来证实，因为目前数据存在高度异质性和潜在的发表偏倚。
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=373228 ，ID：CRD42022373228。
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