Mountain Gregory A, Jelier Benson J, Bagia Christina, Friesen Chadron M, Janjic Jelena M
Department of Chemistry, Saint Francis University, Loretto, PA, 15940, USA.
Department of Chemistry, Trinity Western University, Langley, BC, Canada V2Y 1Y1.
J Fluor Chem. 2014 Jun 1;162:38-44. doi: 10.1016/j.jfluchem.2014.03.007.
This is the first report where PFPAE aromatic conjugates and perfluoro(polyethylene glycol dimethyl ether) are combined and formulated as nanoemulsions with droplet size below 100 nm. A perfluoropolyalkylether (PFPAE) aromatic conjugate, 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene, was used as fluorophilic-hydrophilic diblock (FLD) aimed at stabilizing perfluoro(polyethylene glycol dimethyl ether) nanoemulsions. Its effects on colloidal behaviors in triphasic (organic/fluorous/aqueous) nanoemulsions were studied. The addition of FLD construct to fluorous phase led to decrease in PFPAE nanoemulsion droplet size to as low as 85 nm. Prepared nanoemulsions showed high colloidal stability. Our results suggest that these materials represent viable novel approach to fluorous colloid systems design with potential for biomedical and synthetic applications.
这是首篇关于全氟聚醚芳族共轭物与全氟（聚乙二醇二甲醚）相结合并配制成液滴尺寸低于100纳米的纳米乳液的报告。一种全氟聚醚（PFPAE）芳族共轭物，即2-（聚（六氟环氧丙烷））全氟丙基苯，被用作亲氟-亲水双嵌段（FLD），旨在稳定全氟（聚乙二醇二甲醚）纳米乳液。研究了其对三相（有机/氟相/水相）纳米乳液中胶体行为的影响。向氟相中添加FLD结构导致PFPAE纳米乳液液滴尺寸减小至低至85纳米。制备的纳米乳液表现出高胶体稳定性。我们的结果表明，这些材料代表了一种可行的新型氟相胶体系统设计方法，具有生物医学和合成应用潜力。
