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使用全氟碳探针和氟-19 检测进行体内 MRI 细胞示踪。

In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection.

机构信息

Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

出版信息

NMR Biomed. 2013 Jul;26(7):860-71. doi: 10.1002/nbm.2948. Epub 2013 Apr 22.

DOI:10.1002/nbm.2948
PMID:23606473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3893103/
Abstract

This article presents a brief review of preclinical in vivo cell-tracking methods and applications using perfluorocarbon (PFC) probes and fluorine-19 ((19) F) MRI detection. Detection of the (19) F signal offers high cell specificity and quantification ability in spin density-weighted MR images. We discuss the compositions of matter, methods and applications of PFC-based cell tracking using ex vivo and in situ PFC labeling in preclinical studies of inflammation and cellular therapeutics. We also address the potential applicability of (19) F cell tracking to clinical trials.

摘要

本文简要回顾了使用全氟碳（PFC）探针和氟-19（19 F）MRI 检测进行临床前体内细胞示踪的方法和应用。（19 F）信号的检测在自旋密度加权磁共振图像中提供了高细胞特异性和定量能力。我们讨论了基于 PFC 的细胞示踪的物质组成、方法和应用，包括炎症和细胞治疗的临床前研究中的离体和原位 PFC 标记。我们还探讨了（19 F）细胞示踪在临床试验中的潜在适用性。

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[1]
In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection.

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[2]
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引用本文的文献

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Polymeric (Poly(lactic--glycolic acid)) Particles Entrapping Perfluorocarbons Are Stable for a Minimum of Six Years.

ACS Omega. 2025-2-11

[2]
Cryo-Fluorescence Tomography as a Tool for Visualizing Whole-Body Inflammation Using Perfluorocarbon Nanoemulsion Tracers.

Mol Imaging Biol. 2024-10

[3]
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Curr Top Med Chem. 2024

[4]
Perfluorocarbons: A perspective of theranostic applications and challenges.

Front Bioeng Biotechnol. 2023-8-3

[5]
Fluorinated hydrogel nanoparticles with regulable fluorine contents and relaxation times as F MRI contrast agents.

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[6]
Highlights on U.S. FDA-approved fluorinated drugs over the past five years (2018-2022).

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[7]
Synthesis of 5-Fluorouracil Polymer Conjugate and F NMR Analysis of Drug Release for MRI Monitoring.

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[8]
Superfluorinated Extracellular Vesicles for In Vivo Imaging by F-MRI.

ACS Appl Mater Interfaces. 2023-2-13

[9]
F MRI-fluorescence imaging dual-modal cell tracking with partially fluorinated nanoemulsions.

Front Bioeng Biotechnol. 2022-11-3

[10]
Direct Cell Radiolabeling for Cell Tracking with PET and SPECT Imaging.

Chem Rev. 2022-6-8

本文引用的文献

[1]
¹⁹F MRI tracer preserves in vitro and in vivo properties of hematopoietic stem cells.

Cell Transplant. 2012-8-2

[2]
Fluorine-19 magnetic resonance angiography of the mouse.

PLoS One. 2012-7-27

[3]
Accelerated fluorine-19 MRI cell tracking using compressed sensing.

Magn Reson Med. 2012-7-26

[4]
Visualizing arthritic inflammation and therapeutic response by fluorine-19 magnetic resonance imaging (19F MRI).

J Inflamm (Lond). 2012-6-21

[5]
NIR-labeled perfluoropolyether nanoemulsions for drug delivery and imaging.

J Fluor Chem. 2012-5

[6]
Visualization of inflammation using (19) F-magnetic resonance imaging and perfluorocarbons.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012-3-15

[7]
19F magnetic resonance imaging of endogenous macrophages in inflammation.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012-2-21

[8]
Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI.

Lab Invest. 2012-2-13

[9]
Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRI.

Biomaterials. 2012-1-13

[10]
In vivo tracking of human neural stem cells with 19F magnetic resonance imaging.

PLoS One. 2011-12-28

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