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草药提取物SH003通过抑制STAT3-IL-6信号传导来抑制MDA-MB-231乳腺癌细胞的肿瘤生长和转移。

Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling.

作者信息

Choi Youn Kyung, Cho Sung-Gook, Woo Sang-Mi, Yun Yee Jin, Park Sunju, Shin Yong Cheol, Ko Seong-Gyu

机构信息

Lab of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.

Department of Preventive Medicine, College of Korean Medicine, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 300-716, Republic of Korea.

出版信息

Mediators Inflamm. 2014;2014:492173. doi: 10.1155/2014/492173. Epub 2014 May 25.

DOI:10.1155/2014/492173
PMID:24976685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4058205/
Abstract

Cancer inflammation promotes cancer progression, resulting in a high risk of cancer. Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. Our new herbal formula, SH003, mixed extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii Maximowicz, suppressed MDA-MB-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abilities of MDA-MB-231 cells in vitro. Furthermore, SH003 inhibited STAT3 activation, which resulted in a reduction of IL-6 production. Therefore, we conclude that SH003 suppresses highly metastatic breast cancer growth and metastasis by inhibiting STAT3-IL-6 signaling path.

摘要

癌症炎症促进癌症进展，导致患癌风险升高。在此，我们证明我们的新型草药提取物SH003通过抑制STAT3-IL-6信号通路来抑制MDA-MB-231乳腺癌细胞的肿瘤生长和转移。我们的新型草药配方SH003是黄芪、当归和栝楼的混合提取物，在体内可抑制MDA-MB-231肿瘤生长和肺转移，并在体外降低MDA-MB-231细胞的活力和转移能力。此外，SH003抑制STAT3激活，从而导致IL-6产生减少。因此，我们得出结论，SH003通过抑制STAT3-IL-6信号通路来抑制高转移性乳腺癌的生长和转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/a2d4e800308d/MI2014-492173.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/81cf049b5a47/MI2014-492173.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/b0411a4b6aa6/MI2014-492173.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/3fcd3b5c4d5d/MI2014-492173.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/c7efd09ea98d/MI2014-492173.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/4acc24864220/MI2014-492173.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/a2d4e800308d/MI2014-492173.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/81cf049b5a47/MI2014-492173.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/b0411a4b6aa6/MI2014-492173.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/3fcd3b5c4d5d/MI2014-492173.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/c7efd09ea98d/MI2014-492173.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/4acc24864220/MI2014-492173.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b9d/4058205/a2d4e800308d/MI2014-492173.006.jpg

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Biomed Res Int. 2013;2013:421821. doi: 10.1155/2013/421821. Epub 2013 Oct 2.
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Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up.
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