White S R, Crane G K, Jackson D A
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164.
Ann N Y Acad Sci. 1989;553:337-50. doi: 10.1111/j.1749-6632.1989.tb46655.x.
TRH is found in terminals in the dorsal, lateral, and ventral horns of the spinal cord and apparently has at least a weak facilitatory effect on excitability of neurons in all these locations. These findings suggest that TRH may facilitate transmission in somatosensory pathways, enhance sympathetic outflow from the spinal cord, and facilitate somatic motoneuron excitability, at least transiently. All studies that have examined TRH effects on spinal neuronal excitability have used exogenously administered TRH. Virtually nothing is known about how spinal neuronal functioning might be affected by TRH released from terminals after activation of TRH-containing cell bodies. The acquisition of this knowledge awaits the development of specific TRH antagonists. Preliminary experiments suggest that TRH may have prolonged facilitatory effects on the excitability of developing or damaged spinal cord neurons. Further studies are necessary to determine how TRH interacts with other neuroactive peptides and monoamines to affect excitability of neurons in the developing, damaged, and normal adult spinal cord.
促甲状腺激素释放激素（TRH）存在于脊髓背角、外侧角和腹角的终末中，并且显然对所有这些部位的神经元兴奋性至少有微弱的易化作用。这些发现表明，TRH可能至少在短期内促进躯体感觉通路中的传递，增强脊髓的交感神经传出，并促进躯体运动神经元的兴奋性。所有研究TRH对脊髓神经元兴奋性影响的实验都使用了外源性给予的TRH。对于含TRH的细胞体激活后从终末释放的TRH如何影响脊髓神经元功能，实际上还一无所知。要获得这方面的知识，有待于特异性TRH拮抗剂的研发。初步实验表明，TRH可能对发育中的或受损的脊髓神经元的兴奋性有持久的易化作用。需要进一步研究以确定TRH如何与其他神经活性肽和单胺相互作用，从而影响发育中的、受损的以及正常成年脊髓中神经元的兴奋性。
