Jackson D A, White S R
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164.
Neurosci Lett. 1988 Oct 5;92(2):171-6. doi: 10.1016/0304-3940(88)90055-9.
Thyrotropin releasing hormone (TRH) has been identified recently in fibers and cell bodies in the dorsal horn of the spinal cord, but its function in the dorsal horn is not known. The present study investigated the effects of TRH applied by iontophoresis on the excitability of dorsal horn cells that were responsive to mechanical stimulation of the ipsilateral hindlimb. TRH facilitated glutamate-induced firing of these cells without directly driving the cells in the absence of glutamate. These results suggest that TRH may modulate transmission of somatosensory information in the spinal cord.
促甲状腺激素释放激素（TRH）最近已在脊髓背角的纤维和细胞体中被发现，但其在背角中的功能尚不清楚。本研究通过离子电渗法施加TRH，研究其对响应同侧后肢机械刺激的背角细胞兴奋性的影响。TRH促进了谷氨酸诱导的这些细胞的放电，而在没有谷氨酸的情况下不会直接驱动这些细胞。这些结果表明，TRH可能调节脊髓中躯体感觉信息的传递。
