对称和非对称二甲基氨基吡啶衍生物作为高效胆碱激酶α抑制剂的设计
Design of symmetrical and nonsymmetrical -dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.
作者信息
Trousil Sebastian, Carroll Laurence, Kalusa Andrew, Aberg Ola, Kaliszczak Maciej, Aboagye Eric O
机构信息
Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
出版信息
Medchemcomm. 2013 Apr 1;2013(4):693-696. doi: 10.1039/C3MD00068K.
Abstract
Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.
摘要
胆碱激酶α在许多实体瘤中被高度激活并调节恶性进展，使其成为一个有前景的癌症药物靶点。本文描述了具有高细胞活性的新型抑制剂的成功设计与合成。
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本文引用的文献
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Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors.新型非对称胆碱激酶抑制剂的设计、合成、理论计算与生物评价。
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Metabolic tumor imaging using magnetic resonance spectroscopy.磁共振波谱代谢肿瘤成像。
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