Fekete T, Serfass D A, Lafredo S C, Cundy K R
Department of Microbiology, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140.
Antimicrob Agents Chemother. 1989 Feb;33(2):164-6. doi: 10.1128/AAC.33.2.164.
Using agar dilution, we determined MICs of penicillin, cefoxitin, ceftriaxone, cefmetazole, tetracycline, and spectinomycin for 129 strains of Neisseria gonorrhoeae. All strains were susceptible to ceftriaxone (MIC range, less than or equal to 0.008 to 0.06 micrograms/ml) and spectinomycin (16 to 32 micrograms/ml). The MICs for 50, 90, and 100% of strains tested were 1.0, 2.0, and greater than 8.0 micrograms/ml; 0.12, 1.0, and greater than 8.0 micrograms/ml; 0.5, 1.0, and 2.0 micrograms/ml; and 1.0, 2.0, and greater than 8.0 micrograms/ml for cefmetazole, penicillin, cefoxitin, and tetracycline, respectively. Seven strains were beta-lactamase producers; eight were chromosomally resistant to penicillin. There was a log-linear relation for non-beta-lactamase-producing strains between the MICs of cefmetazole, cefoxitin, and tetracycline and the MIC of penicillin (Pearson r = 0.787, 0.544, and 0.358, respectively).
我们采用琼脂稀释法测定了129株淋病奈瑟菌对青霉素、头孢西丁、头孢曲松、头孢美唑、四环素和壮观霉素的最低抑菌浓度（MIC）。所有菌株对头孢曲松（MIC范围为≤0.008至0.06微克/毫升）和壮观霉素（16至32微克/毫升）均敏感。头孢美唑、青霉素、头孢西丁和四环素对50%、90%和100%受试菌株的MIC分别为1.0、2.0和＞8.0微克/毫升；0.12、1.0和＞8.0微克/毫升；0.5、1.0和2.0微克/毫升；以及1.0、2.0和＞8.0微克/毫升。7株菌株产β-内酰胺酶；8株对青霉素具有染色体耐药性。对于不产β-内酰胺酶的菌株，头孢美唑、头孢西丁和四环素的MIC与青霉素的MIC之间呈对数线性关系（Pearson相关系数r分别为0.787、0.544和0.358）。
